The flumazenil in benzodiazepine intoxication multicenter study group.QRS prolongation on the ECG to suggest a possible co-ingestion with a sodium channel blocking drug (i.e. ![]() ![]() Known or suspected benzodiazepine dependance.Known or suspected co-ingestion of a pro-convulsant.This decision needs to be weighed up with the ability for a ward to manage an infusion and with large adult ingestions it can be easier, quicker and potentially safer to intubate and transfer to ICU Sometimes a flumazenil infusion is warranted.Re-sedation is likely to occur at 90 minutes whereupon further doses will be required.Paediatric dose = 0.01 – 0.02 mg/kg, repeat every minute.Adult dose = 0.1 – 0.2 mg IV and repeat every minute until there is reversal (max dose not exceeding 2mg). ![]()
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